Three British teams might be in action, but the biggest game of the round comes in Spain.
Barcelona welcome Bayern Munich in a truly mouthwatering tie.
It’s a must-watch for many reasons.
One, it’s a game between two of Europe’s biggest teams.
Two, Robert Lewandowski and Hansi Flick take on their former club, with the German manager making a great start to life as Barca boss.
Three, Harry Kane and Lamine Yamal are also involved.
In terms of the teams, the hosts have made just one change from the 5-1 thrashing of Sevilla, with Fermin Lopez coming in for Ansu Fati.
Meanwhile, Vincent Kompany also makes one change from the weekend as Joao Palhinha replaces Aleksandar Pavlovic.
Barcelona: Pena, Kounde, Cubarsi, Martinez, Balde, Pedri, Cassado, Lopez, Yamal, Raphinha, Lewandowski
Subs: Szczesny, Kochen, Gavi, Fati, Torre, Victor, Olmo, De Jong, Fort, Martin, Dominguez
Bayern Munich: Neuer, Guerreiro, Upamecano, Kim, Davies, Kimmich, Palhinha, Olise, Muller, Gnabry, Kane
Subs: Da Peretz, Ulreich, Gortzka, Sane, Coman, Dier, Ibrahimovic, Laimer, Tel, Musiala, Aznou